#cagrilintide 2026-04-05

underwhelming honestly

Verification log updated: SWB — evidence added, status unchanged.

changed my mind on this, i started thinking amylin was the interesting bit and now i think its the pairing

does the fullness effect fade the way appetite suppression does

amylin is about slowed gastric emptying and satiety signalling, thats the short version and im no pharmacologist

REDEFINE is the trial

the slower titration in here is community habit as much as anything, the trials had their own schedule, thats one data point

thats the phase 3 one

anyone dosing this on a different day to their semaglutide

quick one how slow are people titrating this compared to cagrilintide

anyone got two Janoshik results on the same CPC lot for this
the nausea felt different rather than less, more fullness and less of the queasy wave

Testing queue: 3 submissions open, 98 awaiting dispatch.

cagrisema thats it

is the weekly schedule the same here

has REDEFINE reported or are people quoting earlier work

genuine question the combination is the thing with trial data behind it, monotherapy in here is mostly us guessing

right so is the slower titration because of nausea or something else

different not less

CagriSema is cagrilintide with semaglutide and REDEFINE is the trial programme around it

the numbers everyone quotes come from the combination, so comparing them to monotherapy logs is unfair

*Janoshik not the other one

the reason nausea reads differently is timing, mine arrived on the second day rather than the first, someone check my working

fullness rather than nausea