whats REDEFINE testing exactly
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#cagrilintide 2026-03-24
Tuesday22 messages6 participantstimes are UTC
Highlights from this day
- sasha_stacks — whats REDEFINE testing exactly 15:40
- electrolyte_eli — i said earlier this year that monotherapy did nothing for me, and at a higher dose it did something 16:45
- van_isle_vial — amylin is about slowed gastric emptying and satiety signalling, thats the short version and im no pharmacologist 16:49
- van_isle_vial — does the fullness effect fade the way appetite suppression does 20:26
if youre used to GLP-1 titration steps this feels absurdly cautious and i still do it that way, thats one data point
fullness rather than nausea
amylin not glp-1
the combination is the thing with trial data behind it, monotherapy in here is mostly us guessing
held mine a while
how do people separate which of the two is doing what in a combination
combination for me
i said earlier this year that monotherapy did nothing for me, and at a higher dose it did something
coa-f-1330.pdf
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amylin is about slowed gastric emptying and satiety signalling, thats the short version and im no pharmacologist
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added it to an existing tirzepatide dose rather than starting both, which made attribution possible
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the fullness thing is the part people describe differently, food stops being interesting rather than repellent
is the slower titration because of nausea or something else
update on the earlier thing went slower because the first step gave me two rough days and i took that as information
REDEFINE is the trial
thats the phase 3 one
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nobody should copy my schedule, im describing it because people asked what a slow ramp looks like, i have it written down somewhere
monotherapy here
the fullness effect hasnt faded over 24 months, unlike my semaglutide appetite curve
monotherapy was underwhelming for me and i say that as someone who wanted it to work
separate days
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