how slow are people titrating this compared to retatrutide
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#cagrilintide 2026-03-19
Thursday20 messages4 participantstimes are UTC
Highlights from this day
- van_isle_vial — how slow are people titrating this compared to retatrutide 14:58
- van_isle_vial — two Medutest results on the same QYB lot came back 99.4 and 97.4, closer than i expected 15:49
- maintenance_mo — update on the earlier thing lost 81lb over 22 months on the combination and i genuinely cannot apportion it 15:50
- maintenance_mo — right so REDEFINE is the phase 3 programme, most of what gets quoted casually in here is earlier work, anyway amylin is about slowed gastric emptying and satiety… 15:53
- ida_injects — added it to an existing cagrilintide dose rather than starting both, which made attribution possible, thats one data point 18:46
different not less
REDEFINE is the trial
the numbers everyone quotes come from the combination, so comparing them to monotherapy logs is unfair
two Medutest results on the same QYB lot came back 99.4 and 97.4, closer than i expected
update on the earlier thing lost 81lb over 22 months on the combination and i genuinely cannot apportion it
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right so REDEFINE is the phase 3 programme, most of what gets quoted casually in here is earlier work, anyway
amylin is about slowed gastric emptying and satiety signalling, thats the short version and im no pharmacologist
did the combination change your GI compared to the GLP-1 alone
if youre used to GLP-1 titration steps this feels absurdly cautious and i still do it that way
you cannot tell which of the two is doing what in a combination and i stopped pretending i could
amylin is about slowed gastric emptying and satiety signalling, thats the short version and im no pharmacologist
combination GI was worse than either alone for me, which is not what i had read anywhere, not advice obviously
dropped the GLP-1 and stayed on this alone for 23 months, appetite held but weight barely moved
cagrisema thats it
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added it to an existing cagrilintide dose rather than starting both, which made attribution possible, thats one data point
back after 24 months, is monotherapy still a minority thing here
how do people separate which of the two is doing what in a combination
is anyone running this on its own or is it all CagriSema in here
monotherapy here
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weekly for me, same day every week, no reason beyond habit