weekly for me, same day every week, no reason beyond habit, ill dig out the number
#cagrilintide 2025-11-15
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slower than the others
is there a reason people titrate this over more weeks than the others
REDEFINE is the phase 3 programme, most of what gets quoted casually in here is earlier work
held mine a while
i titrated over twice as many weeks as i did on semaglutide and that was right for me
did the nausea feel different to you or just less
held at 2.5 for 6 months on monotherapy before i touched it again, for what its worth
its an amylin analogue, different receptor family, so treating it as another GLP-1 is the first mistake
anyone dosing this on a different day to their cagrilintide
different not less
if youre used to GLP-1 titration steps this feels absurdly cautious and i still do it that way
went slower because the first step gave me two rough days and i took that as information, i think
nobody should copy my schedule, im describing it because people asked what a slow ramp looks like
monotherapy here
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CagriSema is cagrilintide with semaglutide and REDEFINE is the trial programme around it
did the combination change your GI compared to the GLP-1 alone
*Janoshik not the other one
40 in 2.5ml gives 5mg/ml which is what i use, purely because the units come out round
i keep the two on separate days so if something goes wrong i have a chance of knowing which
is the combination just the two dosed together or a single formulation
while im here combination GI was worse than either alone for me, which is not what i had read anywhere
whats REDEFINE testing exactly
the nausea felt different rather than less, more fullness and less of the queasy wave
back after 21 months, is monotherapy still a minority thing here
fridge-thermometer.png
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is the nausea profile genuinely different or am i imagining it
is the slower titration because of nausea or something else
the numbers everyone quotes come from the combination, so comparing them to monotherapy logs is unfair
dosing them on different days made no difference i could detect
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how do people separate which of the two is doing what in a combination
separate days
REDEFINE is the trial
medutest-report-kp-0925.pdf
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the slower titration in here is community habit as much as anything, the trials had their own schedule
amylin is about slowed gastric emptying and satiety signalling, thats the short version and im no pharmacologist
has REDEFINE reported or are people quoting earlier work
thats the phase 3 one
titrating dead slow
Reminder for courier_vs_post: dose day is today. Set 5 days ago.
dropped the GLP-1 and stayed on this alone for 23 months, appetite held but weight barely moved