amylin not glp-1
#cagrilintide 2025-10-14
Tuesday21 messages5 participantstimes are UTC
Highlights from this day
- amylin_amy — the nausea felt different rather than less, more fullness and less of the queasy wave 20:00
- two_labs_two_answers — the slower titration in here is community habit as much as anything, the trials had their own schedule, thats just me 20:13
- two_labs_two_answers — two Janoshik results on the same GL Biochem lot came back 96.8 and 99, closer than i expected 20:27
- amylin_amy — does the fullness effect fade the way appetite suppression does i was sceptical about monotherapy and after 25 months im still sceptical, just less so 21:21
CagriSema is cagrilintide with semaglutide and REDEFINE is the trial programme around it
the nausea felt different rather than less, more fullness and less of the queasy wave
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the slower titration in here is community habit as much as anything, the trials had their own schedule, thats just me
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for the archive went slower because the first step gave me two rough days and i took that as information
slower than the others
two Janoshik results on the same GL Biochem lot came back 96.8 and 99, closer than i expected
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the reason nausea reads differently is timing, mine arrived on the second day rather than the first
update on the earlier thing dropped the GLP-1 and stayed on this alone for 17 months, appetite held but weight barely moved, ymmv
i was sceptical about monotherapy and after 2 months im still sceptical, just less so
ok so i titrated over twice as many weeks as i did on semaglutide and that was right for me
changed my mind on this, i started thinking amylin was the interesting bit and now i think its the pairing
stopped for 9 months and the fullness went within a fortnight of the last dose
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its an amylin analogue, different receptor family, so treating it as another GLP-1 is the first mistake, anyway
the fullness thing is the part people describe differently, food stops being interesting rather than repellent, thats just me
anyone dosing this on a different day to their semaglutide
does the fullness effect fade the way appetite suppression does
i was sceptical about monotherapy and after 25 months im still sceptical, just less so
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quick one monotherapy was underwhelming for me and i say that as someone who wanted it to work
two_labs_two_answersthe reason nausea reads differently is timing, mine arrived on the second day rather…
coming back to this REDEFINE is the phase 3 programme, most of what gets quoted casually in here is earlier work, n of 1 obviously
nobody should copy my schedule, im describing it because people asked what a slow ramp looks like
combination GI was worse than either alone for me, which is not what i had read anywhere