amylin not glp-1
#cagrilintide 2025-10-04
Saturday39 messages9 participantstimes are UTC
Highlights from this day
REDEFINE is the phase 3 programme, most of what gets quoted casually in here is earlier work
peptidemeter-summary-e-2205.pdf
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separate days
fridge-thermometer.png
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genuine question combination GI was worse than either alone for me, which is not what i had read anywhere
amylin is about slowed gastric emptying and satiety signalling, thats the short version and im no pharmacologist
is the combination just the two dosed together or a single formulation
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added it to an existing tirzepatide dose rather than starting both, which made attribution possible
i titrated over twice as many weeks as i did on semaglutide and that was right for me, ymmv
is the weekly schedule the same here
the fullness thing is the part people describe differently, food stops being interesting rather than repellent
£240 for a 10 vial and it lasts me longer than the GLP-1 does at my doses
the nausea felt different rather than less, more fullness and less of the queasy wave
how many weeks before you noticed anything on monotherapy
update on the earlier thing 15 in 2.5ml gives 10mg/ml which is what i use, purely because the units come out round, we shall see
i keep the two on separate days so if something goes wrong i have a chance of knowing which
the combination is the thing with trial data behind it, monotherapy in here is mostly us guessing
did anyone add this to an existing cagrilintide dose rather than starting both
cant separate them
underwhelming honestly
whats REDEFINE testing exactly
Inter-lab diff for lot F-1330: 99.2% vs 99%. Within expected range.
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cagrisema thats it
dosing them on different days made no difference i could detect
the slower titration in here is community habit as much as anything, the trials had their own schedule, from memory
the numbers everyone quotes come from the combination, so comparing them to monotherapy logs is unfair
titrating dead slow
how do people separate which of the two is doing what in a combination
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monotherapy here
does the fullness effect fade the way appetite suppression does
you cannot tell which of the two is doing what in a combination and i stopped pretending i could, ill dig out the number
held at 7.5 for 3 months on monotherapy before i touched it again
anyone holding at 2.4 for a while before stepping
update on the earlier thing stopped for 7 months and the fullness went within a fortnight of the last dose
two Medutest results on the same WXT lot came back 97.4 and 96.8, closer than i expected
dropped the GLP-1 and stayed on this alone for 7 months, appetite held but weight barely moved
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different not less
amylin analogue, so its not a GLP-1 at all right
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