changed my mind on this, i started thinking amylin was the interesting bit and now i think its the pairing
#cagrilintide 2025-09-09
Tuesday23 messages6 participantstimes are UTC
Highlights from this day
- ring_size_down — i titrated over twice as many weeks as i did on semaglutide and that was right for me its an amylin analogue, different receptor family, so treating it as another… 17:54
- amylin_amy — nobody should copy my schedule, im describing it because people asked what a slow ramp looks like noticed something around week 11 on monotherapy, well after i had… 18:16
- amylin_amy — i keep the two on separate days so if something goes wrong i have a chance of knowing which 18:59
- amylin_amy — right so you cannot tell which of the two is doing what in a combination and i stopped pretending i could 19:44
does amylin do something about fullness that the GLP-1 doesnt
REDEFINE is the phase 3 programme, most of what gets quoted casually in here is earlier work
underwhelming honestly
if youre used to GLP-1 titration steps this feels absurdly cautious and i still do it that way
i titrated over twice as many weeks as i did on semaglutide and that was right for me
its an amylin analogue, different receptor family, so treating it as another GLP-1 is the first mistake
sorry to jump in did anyone add this to an existing retatrutide dose rather than starting both
nobody should copy my schedule, im describing it because people asked what a slow ramp looks like
noticed something around week 11 on monotherapy, well after i had given up expecting to
slightly off topic but did the nausea feel different to you or just less
its an amylin analogue, different receptor family, so treating it as another GLP-1 is the first mistake
dropped the GLP-1 and stayed on this alone for 19 months, appetite held but weight barely moved
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the numbers everyone quotes come from the combination, so comparing them to monotherapy logs is unfair
ok so how do people separate which of the two is doing what in a combination
i keep the two on separate days so if something goes wrong i have a chance of knowing which
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monotherapy was underwhelming for me and i say that as someone who wanted it to work, i could be wrong
held mine a while
thats the phase 3 one
right so you cannot tell which of the two is doing what in a combination and i stopped pretending i could
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ok so stopped for 24 months and the fullness went within a fortnight of the last dose
weekly for me, same day every week, no reason beyond habit
went slower because the first step gave me two rough days and i took that as information
amylin not glp-1
combination for me
cant separate them
CagriSema is cagrilintide with semaglutide and REDEFINE is the trial programme around it