the fullness thing is the part people describe differently, food stops being interesting rather than repellent
#cagrilintide 2025-08-08
Friday30 messages9 participantstimes are UTC
Highlights from this day
- lyophile_liv — amylin analogue, so its not a GLP-1 at all right 18:08
- apob_over_ldl — i titrated over twice as many weeks as i did on semaglutide and that was right for me, ill dig out the number 18:37
- careful_claims — went slower because the first step gave me two rough days and i took that as information 19:20
- apob_over_ldl — held at 15 for 4 months on monotherapy before i touched it again 19:28
you cannot tell which of the two is doing what in a combination and i stopped pretending i could
right so the fullness effect hasnt faded over 3 months, unlike my semaglutide appetite curve
is the nausea profile genuinely different or am i imagining it
[edited]monotherapy was underwhelming for me and i say that as someone who wanted it to work, i could be wrong
weekly for me, same day every week, no reason beyond habit
combination for me
amylin is about slowed gastric emptying and satiety signalling, thats the short version and im no pharmacologist
[edited]whats REDEFINE testing exactly
titrating dead slow
monotherapy here
amylin analogue, so its not a GLP-1 at all right
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thats the phase 3 one
the combination is the thing with trial data behind it, monotherapy in here is mostly us guessing, anyway
[edited]its an amylin analogue, different receptor family, so treating it as another GLP-1 is the first mistake, thats one data point
£55 for a 2 vial and it lasts me longer than the GLP-1 does at my doses
i titrated over twice as many weeks as i did on semaglutide and that was right for me, ill dig out the number
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whats the recon people use, 15 in 1.5ml
held mine a while
went slower because the first step gave me two rough days and i took that as information
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REDEFINE is the phase 3 programme, most of what gets quoted casually in here is earlier work
did the combination change your GI compared to the GLP-1 alone
is 2.4 the number for this too or am i confusing compounds
held at 15 for 4 months on monotherapy before i touched it again
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dropped the GLP-1 and stayed on this alone for 6 months, appetite held but weight barely moved
lost 93lb over 16 months on the combination and i genuinely cannot apportion it
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cant separate them
Reminder for lyophile_liv: dose day is today. Set 3 days ago.
slower than the others
$240 for a 40 vial and it lasts me longer than the GLP-1 does at my doses