whats REDEFINE testing exactly
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#cagrilintide 2025-07-14
Monday31 messages8 participantstimes are UTC
Highlights from this day
amylin not glp-1
held mine a while
genuine question did anyone find monotherapy underwhelming
ok so monotherapy was underwhelming for me and i say that as someone who wanted it to work
nobody should copy my schedule, im describing it because people asked what a slow ramp looks like, for what its worth
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different not less
medutest-report-d-0718.pdf
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amylin analogue, so its not a GLP-1 at all right
how many weeks before you noticed anything on monotherapy
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stopped for 19 months and the fullness went within a fortnight of the last dose
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the fullness thing is the part people describe differently, food stops being interesting rather than repellent
changed my mind on this, i started thinking amylin was the interesting bit and now i think its the pairing
if youre used to GLP-1 titration steps this feels absurdly cautious and i still do it that way
REDEFINE is the trial
[edited]cant separate them
combination GI was worse than either alone for me, which is not what i had read anywhere
[edited]amylin is about slowed gastric emptying and satiety signalling, thats the short version and im no pharmacologist, i have it written down somewhere
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separate days
New independent result logged — SGN, lot G-0641, purity 99.4% (Janoshik).
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went slower because the first step gave me two rough days and i took that as information
slower than the others
did anyone add this to an existing cagrilintide dose rather than starting both
added it to an existing tirzepatide dose rather than starting both, which made attribution possible
monotherapy here
monotherapy question, did appetite move for you without a GLP-1 alongside
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right so the combination is the thing with trial data behind it, monotherapy in here is mostly us guessing
£94 for a 2 vial and it lasts me longer than the GLP-1 does at my doses
the numbers everyone quotes come from the combination, so comparing them to monotherapy logs is unfair
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the nausea felt different rather than less, more fullness and less of the queasy wave
anyone got two Janoshik results on the same SGN lot for this
lost 21lb over 10 months on the combination and i genuinely cannot apportion it