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#cagrilintide 2025-06-15

Sunday27 messages8 participantstimes are UTC
Highlights from this day
  • igf_one_ivy — how do people separate which of the two is doing what in a combination 15:45
  • coelution_cai — if youre used to GLP-1 titration steps this feels absurdly cautious and i still do it that way 16:43
  • coelution_cai — two Medutest results on the same TFC lot came back 98.1 and 99.2, closer than i expected, i have it written down somewhere 18:02
CC

amylin not glp-1

Cited study
Efficacy and Safety of Cagrilintide in Adults with Overweight or Obesity — Phase 2
The Lancet · 2021
Cagrilintide monotherapy, dose ranging. The combination trials came later.
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combination GI was worse than either alone for me, which is not what i had read anywhere

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IO

how do people separate which of the two is doing what in a combination

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REDEFINE is the trial

monotherapy was underwhelming for me and i say that as someone who wanted it to work

*that should say weekly

CC

amylin is about slowed gastric emptying and satiety signalling, thats the short version and im no pharmacologist

noticed something around week 29 on monotherapy, well after i had given up expecting to

monotherapy question, did appetite move for you without a GLP-1 alongside

the nausea felt different rather than less, more fullness and less of the queasy wave

CC

if youre used to GLP-1 titration steps this feels absurdly cautious and i still do it that way

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VB

New independent result logged — GGPeps, lot SG-1177, purity 99.2% (PeptideMeter).

CC

amylin analogue, so its not a GLP-1 at all right
added it to an existing semaglutide dose rather than starting both, which made attribution possible

CC

two Medutest results on the same TFC lot came back 98.1 and 99.2, closer than i expected, i have it written down somewhere

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CH

you cannot tell which of the two is doing what in a combination and i stopped pretending i could

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lost 74lb over 1 months on the combination and i genuinely cannot apportion it

fullness rather than nausea

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did anyone add this to an existing retatrutide dose rather than starting both

CC

the fullness thing is the part people describe differently, food stops being interesting rather than repellent

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is the weekly schedule the same here