unrelated but lost 97lb over 25 months on the combination and i genuinely cannot apportion it
#cagrilintide 2025-06-07
Saturday26 messages4 participantstimes are UTC
Highlights from this day
- mhra_unlicensed — i titrated over twice as many weeks as i did on semaglutide and that was right for me 19:33
- mhra_unlicensed — unrelated but amylin is about slowed gastric emptying and satiety signalling, thats the short version and im no pharmacologist 20:00
- coffee_only — changed my mind on this, i started thinking amylin was the interesting bit and now i think its the pairing 21:24
REDEFINE is the phase 3 programme, most of what gets quoted casually in here is earlier work
is the slower titration because of nausea or something else
is the combination just the two dosed together or a single formulation
weekly for me, same day every week, no reason beyond habit
fullness rather than nausea
amylin not glp-1
combination for me
i titrated over twice as many weeks as i did on semaglutide and that was right for me
janoshik-sg-1177.pdf
2 pages · 205 KB · not retained in the public archive
cagrisema thats it
unrelated but amylin is about slowed gastric emptying and satiety signalling, thats the short version and im no pharmacologist
the slower titration in here is community habit as much as anything, the trials had their own schedule
separate days
dosing them on different days made no difference i could detect
underwhelming honestly
added it to an existing semaglutide dose rather than starting both, which made attribution possible, anyway
sorry to jump in anyone stopped the GLP-1 and kept only this
i was sceptical about monotherapy and after 25 months im still sceptical, just less so
CagriSema is cagrilintide with semaglutide and REDEFINE is the trial programme around it
changed my mind on this, i started thinking amylin was the interesting bit and now i think its the pairing
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*Medutest not the other one
the fullness thing is the part people describe differently, food stops being interesting rather than repellent
the numbers everyone quotes come from the combination, so comparing them to monotherapy logs is unfair
titrating dead slow
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if youre used to GLP-1 titration steps this feels absurdly cautious and i still do it that way