separate days
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#cagrilintide 2025-03-28
Friday31 messages8 participantstimes are UTC
Highlights from this day
- impersonator_ip — did the combination change your GI compared to the GLP-1 alone 18:48
- rotate_the_site — its an amylin analogue, different receptor family, so treating it as another GLP-1 is the first mistake 19:00
- impersonator_ip — two Medutest results on the same Homopeptide lot came back 99.4 and 99, closer than i expected 21:16
did the combination change your GI compared to the GLP-1 alone
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is the combination just the two dosed together or a single formulation
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its an amylin analogue, different receptor family, so treating it as another GLP-1 is the first mistake
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i keep the two on separate days so if something goes wrong i have a chance of knowing which
Recon calculator: 15mg in 5ml = 4mg/ml.
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slightly off topic but the reason nausea reads differently is timing, mine arrived on the second day rather than the first
underwhelming honestly
slower than the others
the slower titration in here is community habit as much as anything, the trials had their own schedule
Reminder for impersonator_ip: dose day is today. Set 6 days ago.
the combination is the thing with trial data behind it, monotherapy in here is mostly us guessing
combination GI was worse than either alone for me, which is not what i had read anywhere
held at 5 for 6 months on monotherapy before i touched it again
anyone dosing this on a different day to their semaglutide
REDEFINE is the phase 3 programme, most of what gets quoted casually in here is earlier work
monotherapy here
slightly off topic but stopped for 18 months and the fullness went within a fortnight of the last dose, ask me again in a month
thats the phase 3 one
CagriSema is cagrilintide with semaglutide and REDEFINE is the trial programme around it, i think
€72 for a 10 vial and it lasts me longer than the GLP-1 does at my doses, not advice obviously
nobody should copy my schedule, im describing it because people asked what a slow ramp looks like, ymmv
back after 19 months, is monotherapy still a minority thing here
different not less
i titrated over twice as many weeks as i did on semaglutide and that was right for me
how do people separate which of the two is doing what in a combination
[edited]two Medutest results on the same Homopeptide lot came back 99.4 and 99, closer than i expected
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the fullness effect hasnt faded over 24 months, unlike my semaglutide appetite curve
noticed something around week 17 on monotherapy, well after i had given up expecting to
anyone stopped the GLP-1 and kept only this