CagriSema is cagrilintide with semaglutide and REDEFINE is the trial programme around it
#cagrilintide 2025-03-08
Saturday43 messages9 participantstimes are UTC
Highlights from this day
- taper_or_not — two Janoshik results on the same Homopeptide lot came back 99 and 99.4, closer than i expected 22:01
- impersonator_ip — REDEFINE is the phase 3 programme, most of what gets quoted casually in here is earlier work 22:40
- impersonator_ip — right so back after 24 months, is monotherapy still a minority thing here 22:54
- impersonator_ip — weekly for me, same day every week, no reason beyond habit, your mileage will differ 23:37
- amylin_amy — the nausea felt different rather than less, more fullness and less of the queasy wave, thats just me 23:49
two Janoshik results on the same Homopeptide lot came back 99 and 99.4, closer than i expected
the numbers everyone quotes come from the combination, so comparing them to monotherapy logs is unfair
slower than the others
if youre used to GLP-1 titration steps this feels absurdly cautious and i still do it that way
whats the recon people use, 30 in 5ml
monotherapy here
thats the phase 3 one
i titrated over twice as many weeks as i did on semaglutide and that was right for me
stopped for 15 months and the fullness went within a fortnight of the last dose
anyone holding at 2 for a while before stepping
the slower titration in here is community habit as much as anything, the trials had their own schedule
held at 0.25 for 5 months on monotherapy before i touched it again
lost 104lb over 16 months on the combination and i genuinely cannot apportion it
sorry to jump in monotherapy did work for me, just slower and smaller than i expected
whats REDEFINE testing exactly
the fullness thing is the part people describe differently, food stops being interesting rather than repellent
i was sceptical about monotherapy and after 12 months im still sceptical, just less so
amylin not glp-1
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added it to an existing retatrutide dose rather than starting both, which made attribution possible, not advice obviously
REDEFINE is the phase 3 programme, most of what gets quoted casually in here is earlier work
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the fullness effect hasnt faded over 16 months, unlike my semaglutide appetite curve
you cannot tell which of the two is doing what in a combination and i stopped pretending i could
did the combination change your GI compared to the GLP-1 alone
dropped the GLP-1 and stayed on this alone for 26 months, appetite held but weight barely moved
did the nausea feel different to you or just less
[edited]the reason nausea reads differently is timing, mine arrived on the second day rather than the first
right so back after 24 months, is monotherapy still a minority thing here
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underwhelming honestly
is the nausea profile genuinely different or am i imagining it
coming back to this is anyone running this on its own or is it all CagriSema in here
does amylin do something about fullness that the GLP-1 doesnt
cant separate them
anyone stopped the GLP-1 and kept only this
Testing queue: 3 submissions open, 21 awaiting dispatch.
unrelated but i said earlier this year that monotherapy did nothing for me, and at a higher dose it did something
how many weeks before you noticed anything on monotherapy
did anyone add this to an existing retatrutide dose rather than starting both
10 in 3ml gives 2mg/ml which is what i use, purely because the units come out round
nobody should copy my schedule, im describing it because people asked what a slow ramp looks like, i think
weekly for me, same day every week, no reason beyond habit, your mileage will differ
the combination is the thing with trial data behind it, monotherapy in here is mostly us guessing
*VendorInvestigate not the other one
the nausea felt different rather than less, more fullness and less of the queasy wave, thats just me
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