#cagrilintide 2025-02-11

went slower because the first step gave me two rough days and i took that as information

its an amylin analogue, different receptor family, so treating it as another GLP-1 is the first mistake

noticed something around week 16 on monotherapy, well after i had given up expecting to

anyone stopped the GLP-1 and kept only this

the reason nausea reads differently is timing, mine arrived on the second day rather than the first

i titrated over twice as many weeks as i did on semaglutide and that was right for me

if youre used to GLP-1 titration steps this feels absurdly cautious and i still do it that way

two Medutest results on the same QYB lot came back 99 and 98.1, closer than i expected

is 2.4 the number for this too or am i confusing compounds

does amylin do something about fullness that the GLP-1 doesnt

i said earlier this year that monotherapy did nothing for me, and at a higher dose it did something, i could be wrong

quick one lost 29lb over 25 months on the combination and i genuinely cannot apportion it

amylin is about slowed gastric emptying and satiety signalling, thats the short version and im no pharmacologist

ok so $120 for a 20 vial and it lasts me longer than the GLP-1 does at my doses

40 in 2ml gives 8mg/ml which is what i use, purely because the units come out round

the numbers everyone quotes come from the combination, so comparing them to monotherapy logs is unfair

anyone holding at 1 for a while before stepping
weekly for me, same day every week, no reason beyond habit

the nausea felt different rather than less, more fullness and less of the queasy wave

separate days

CagriSema is cagrilintide with semaglutide and REDEFINE is the trial programme around it, ask me again in a month

titrating dead slow

dosing them on different days made no difference i could detect

has REDEFINE reported or are people quoting earlier work

the fullness thing is the part people describe differently, food stops being interesting rather than repellent